Fresh analysis suggests that patients who come off popular slimming jabs like semaglutide or tirzepatide may regain reduced body mass much more quickly than those who stop conventional lifestyle plans.
Published data in a leading health publication points out that while overweight individuals frequently drop substantial amounts of their body weight while undergoing treatment, the weight is regained at an average rate of 0.8 kg per month upon discontinuation.
"Individuals purchasing these drugs should be aware of the risk of quick rebound weight gain when the medication ends," cautioned researcher Dr. Susan Jebb.
That rate of regain suggests a return to original mass within about 18 months.
Weighing Approaches
The research, which examined dozens of trials involving thousands of participants, compared the results of the injectable medications with older methods.
Researchers note that individuals who lose weight through dieting usually have a more gradual weight regain—approximately 100 grams monthly—post-intervention.
Understanding the Rapid Rebound
Experts propose the mode of action of the injections explains the amplified regain.
GLP-1 drugs mimic a body's own chemical called glucagon-like peptide-1, which moderates feelings of fullness.
"Artificially providing the hormone concentrations far above than normal might result in the system to produce less of its own natural hormone, and could lessen responsiveness to its actions," explained Dr. Adam Collins, a nutrition researcher.
"Discontinuation of this medication means appetite is unsuppressed, making excessive eating a significant risk."
A Lifelong Condition?
Health authorities advise the injections for people with obesity-related medical conditions, accompanied by recommended diet and exercise modifications.
A number of clinicians contend that, considering the likelihood of relapse, the therapy should be considered life-long.
This opinion is supported by pharmaceutical companies, who note that the findings "highlight the long-term character of obesity," comparing it to managing conditions like diabetes.
User Experiences
People who have stopped the jabs describe a sudden return of hunger.
"It felt as if a trigger that goes on and I was suddenly ravenous," said a patient.
The struggle is compounded if individuals have not established lasting lifestyle or habit modifications during treatment.
Significant Adoption
Figures indicate that millions of people in the UK have used weight-loss jabs in the last 12 months, with demand remaining high.
- Use is greater among females compared to males.
- The 40s and 50s age group shows the greatest usage rates.
- A large proportion obtain the medications through private healthcare rather than the NHS.
Ultimately, experts stress that while these medications are potent agents for weight loss, they are not a standalone solution and maintained weight loss hinges on combined behavioural changes.
